old Grump
08-07-2010, 12:18 AM
Scientists decode 5,200-year-old Iceman’s genes
Genetic data could point to ancient traits ... or modern relatives
© South Tyrol Museum of Archaeology
Researchers have sequenced Oetzi the Iceman's genome and hope to be able to locate any living descendants.
By Wynne Parry
updated 8/5/2010 1:48:58 PM ET
Oetzi the Iceman, the Neolithic mummy found accidentally in the eastern Alps by German hikers in 1991, has offered researchers all sorts of clues to life 5,200 years ago, from his goat-hide coat to the meat and unleavened bread in his stomach to the arrow wound in his shoulder.
http://msnbcmedia1.msn.com/j/MSNBC/Components/Photo/_new/100805-science-iceman-vmed-1040a.grid-4x2.jpg
Now scientists stand poised to find out a whole lot more about Iceman, who also goes by Frozen Fritz and Similaun Man.
They recently finished sequencing the Iceman's genome, which took about three months — a feat made possible by whole genome sequencing technology. With that map of his genes in hand, researchers are moving onto to a whole new array of questions, according to Albert Zink, head of the European Institute for Mummies and the Iceman at the European Academy of Bozen/Bolzano (EURAC) in Italy.
"Some are very simple, like so 'What was really the eye color of the Iceman? What was really his hair color?'" Zink said. There are more complicated questions, too. Zink and others are curious about any genetic evidence of disease in the Iceman and the composition of his immune system.
And there's the big one, he told LiveScience: "Are there any living relatives of the Iceman still around?"
Scientists have already taken a stab at this question when they analyzed DNA from Iceman's mitochondria energy-producing centers of cells and compared the results with groups of living individuals. They did not find any matches, suggesting that his maternal lineage is either very rare or died out. (Mitochondrial DNA is passed down from mothers to their children and so would only provide relatives on Iceman's mom's side of the family.)
"We have to take into account this is only the maternal lineage," he said, referring to the mitochondrial study. "And not all people are tested."
Until now, scientists hadn't mapped the DNA within the nuclei of his cells. For humans, nuclear DNA contains 6 billion base pairs, while mitochondrial DNA has only 15,000 to 17,000, according to Zink.
Collaboration with EURAC's Institute for Genetic Medicine is expected to widen the field, because it has collected genetic information on a large number of people living in the region, the most likely prospects for Iceman's descendants. That, in addition to the fact that scientists can compare his entire nuclear genome, gives Zink hope for getting to the bottom of some of Iceman's mysteries.
Iceman's genome was sequenced using a sample taken previously from his hip bone, Zink said.
Zink and a colleague from the Institute of Human Genetics at the University of Tuebingen were able to complete the genomic sequencing with amazing speed thanks to collaboration with Andreas Keller of the biotechnology firm Febit, according to Zink.
http://www.msnbc.msn.com/id/38578491/ns/technology_and_science-science
It boggles me little mind how we keep finding out things supposedly lost for the ages. I hope they don't come up with a mind reading machine. There are things forgotten or should be forgotten that most of us hope never see the day of life again. Levity aside I find this whole exercise in studying the iceman fascinating and I can't wait to see what else they come up with.
I'd really like to see the results of the genome analysis and how it connects to modern man. Anybody missing a great great great great great grand uncle from their family tree. Anybody know how many greats it takes to go back 5,200 years. I'm guessing about 133 if you have another generation every 30 years but I'm probably being to conservative.
Genetic data could point to ancient traits ... or modern relatives
© South Tyrol Museum of Archaeology
Researchers have sequenced Oetzi the Iceman's genome and hope to be able to locate any living descendants.
By Wynne Parry
updated 8/5/2010 1:48:58 PM ET
Oetzi the Iceman, the Neolithic mummy found accidentally in the eastern Alps by German hikers in 1991, has offered researchers all sorts of clues to life 5,200 years ago, from his goat-hide coat to the meat and unleavened bread in his stomach to the arrow wound in his shoulder.
http://msnbcmedia1.msn.com/j/MSNBC/Components/Photo/_new/100805-science-iceman-vmed-1040a.grid-4x2.jpg
Now scientists stand poised to find out a whole lot more about Iceman, who also goes by Frozen Fritz and Similaun Man.
They recently finished sequencing the Iceman's genome, which took about three months — a feat made possible by whole genome sequencing technology. With that map of his genes in hand, researchers are moving onto to a whole new array of questions, according to Albert Zink, head of the European Institute for Mummies and the Iceman at the European Academy of Bozen/Bolzano (EURAC) in Italy.
"Some are very simple, like so 'What was really the eye color of the Iceman? What was really his hair color?'" Zink said. There are more complicated questions, too. Zink and others are curious about any genetic evidence of disease in the Iceman and the composition of his immune system.
And there's the big one, he told LiveScience: "Are there any living relatives of the Iceman still around?"
Scientists have already taken a stab at this question when they analyzed DNA from Iceman's mitochondria energy-producing centers of cells and compared the results with groups of living individuals. They did not find any matches, suggesting that his maternal lineage is either very rare or died out. (Mitochondrial DNA is passed down from mothers to their children and so would only provide relatives on Iceman's mom's side of the family.)
"We have to take into account this is only the maternal lineage," he said, referring to the mitochondrial study. "And not all people are tested."
Until now, scientists hadn't mapped the DNA within the nuclei of his cells. For humans, nuclear DNA contains 6 billion base pairs, while mitochondrial DNA has only 15,000 to 17,000, according to Zink.
Collaboration with EURAC's Institute for Genetic Medicine is expected to widen the field, because it has collected genetic information on a large number of people living in the region, the most likely prospects for Iceman's descendants. That, in addition to the fact that scientists can compare his entire nuclear genome, gives Zink hope for getting to the bottom of some of Iceman's mysteries.
Iceman's genome was sequenced using a sample taken previously from his hip bone, Zink said.
Zink and a colleague from the Institute of Human Genetics at the University of Tuebingen were able to complete the genomic sequencing with amazing speed thanks to collaboration with Andreas Keller of the biotechnology firm Febit, according to Zink.
http://www.msnbc.msn.com/id/38578491/ns/technology_and_science-science
It boggles me little mind how we keep finding out things supposedly lost for the ages. I hope they don't come up with a mind reading machine. There are things forgotten or should be forgotten that most of us hope never see the day of life again. Levity aside I find this whole exercise in studying the iceman fascinating and I can't wait to see what else they come up with.
I'd really like to see the results of the genome analysis and how it connects to modern man. Anybody missing a great great great great great grand uncle from their family tree. Anybody know how many greats it takes to go back 5,200 years. I'm guessing about 133 if you have another generation every 30 years but I'm probably being to conservative.